Aluminium lithium hydride → 2-[cis-5-Amino-1-benzylpiperidin-2-yl]ethanol

Temperature

0 °C

To a stirred suspension of lithium aluminum hydride (97 mg, 2.55 mmol) in tetrahydrofuran (5 mL) was added a solution of ethyl [cis-5-amino-1-benzylpiperidin-2-yl]acetate (352 mg, 1.27 mmol, step 7 of Example 1) in tetrahydrofuran (4 mL) at 0° C., and the mixture was stirred at 0° C. for 1 h, then stirred at room temperature for 1 h. The mixture was quenched with water (0.1 mL) at 0° C., and stirred for 30 min at 0° C. 15% aqueous sodium hydroxide solution (0.1 mL) was added at 0° C., and the mixture was stirred at room temperature for 30 min. Water (0.3 mL) was added, and the mixture was stirred at room temperature for 30 min. The mixture was filtered through Celte pad washing with tetrahydrofuran (100 mL). The filtrate was concentrated under reduced pressure to give 322 mg (quant.) of the title compound as a slightly yellow oil.

1. stirringstirred at room temperature for 1 h
2. customThe mixture was quenched with water (0.1 mL) at 0° C.
3. stirringstirred for 30 min at 0° C
4. addition15% aqueous sodium hydroxide solution (0.1 mL) was added at 0° C.
5. stirringthe mixture was stirred at room temperature for 30 min
6. additionWater (0.3 mL) was added
7. stirringthe mixture was stirred at room temperature for 30 min
8. filtrationThe mixture was filtered through Celte pad
9. washwashing with tetrahydrofuran (100 mL)
10. concentrationThe filtrate was concentrated under reduced pressure

ORD record

ord-e1d44e6c320a419f886d501f2c4a6ad1

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07906532B2