反应详情

(3-Benzyloxy-5-trifluoromethyl-benzyl)-(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amine (215 mg) is dissolved in methanol (10.5 ml), and thereto is added 10% palladium-carbon and the mixture is stirred under hydrogen atmosphere at room temperature for 1 hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The resulting residue is purified by NH-silica gel column chromatography (hexane:ethyl acetate=4:1→1:2, and chloroform:methanol 19:1→9:1) to give 3-{[(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenol (98 mg). MS (m/z): 661 [M+H]+

1. customThe catalyst is removed by filtration
2. concentrationthe filtrate is concentrated under reduced pressure
3. customThe resulting residue is purified by NH-silica gel column chromatography (hexane:ethyl acetate=4:1→1:2, and chloroform:methanol 19:1→9:1)