反应详情

Then, Et3SiH (1.62 mL, 10.1 mmol) and BF3.Et2O (0.772 mL, 6.09 mmol) were added sequentially to a chloroform-acetonitrile (1:1; 16 mL) solution of (5-bromo-2-chloro-6-methoxyphenyl)(4-ethoxyphenyl)methanone (1.50 g, 4.06 mmol) at −5° C. The reaction mixture was warmed to room temperature and stirred for 16 hours. After the reaction mixture was added with a saturated sodium carbonate aqueous solution and extracted with chloroform, the organic layer was washed with brine and dried with anhydrous magnesium sulfate. After the desiccant was filtered off, the residue obtained by evaporating the solvent under reduced pressure was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to obtain a colorless oily title compound (1.48 g, 99%).

1. extractionextracted with chloroform
2. washthe organic layer was washed with brine
3. dry with materialdried with anhydrous magnesium sulfate
4. filtrationAfter the desiccant was filtered off
5. customthe residue obtained
6. customby evaporating the solvent under reduced pressure
7. customwas purified by silica gel column chromatography (hexane:ethyl acetate=20:1)