反应详情

To a solution of [4-(3-phenyl-1,7-naphthyridin-2-yl)phenyl]methanol (142 mg, 0.455 mmol) in chloroform (3 mL) was added a solution of m-chloroperbenzoic acid (85%, 105 mg, 0.47 mmol) in chloroform (2 mL). The reaction was stirred over night and then the solvent was removed in vacuo. The residue was digested with diethyl ether twice to remove the m-chlorobenzoic acid and give the title compound as a yellow solid. 1H-NMR (500 MHz, CDCl3): δ 9.07 (1H, s), 8.24 (1H, d, J=6.8 Hz), 8.09 (1H, s), 7.70 (1H, d, J=7.1 Hz), 7.41 (2H, d, J=8.1 Hz), 7.22-7.39 (7H, m), 4.71 (2H, s). m/e (m+1): 329.2.

1. customthe solvent was removed in vacuo
2. customto remove the m-chlorobenzoic acid