Trifluoroacetic acid → HCID 178489120, compound

HRID 605016Notes

Reaction equation

HRID 605016 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[NH:10][C:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]5[C:36]([C:37]6[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=6)=[CH:35][C:34]6[C:33](=[O:43])[NH:32][CH:31]=[CH:30][C:29]=6[N:28]=5)=[CH:23][CH:22]=4)[CH2:16][CH2:15]3)=[N:12][N:13]=2)=[CH:5][CH:4]=1.[C:44]([OH:50])([C:46]([F:49])([F:48])[F:47])=[O:45]>CO>[F:47][C:46]([F:49])([F:48])[C:44]([OH:50])=[O:45].[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[NH:10][C:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][C:21]4[CH:22]=[CH:23][C:24]([C:27]5[C:36]([C:37]6[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=6)=[CH:35][C:34]6[C:33](=[O:43])[NH:32][CH:31]=[CH:30][C:29]=6[N:28]=5)=[CH:25][CH:26]=4)[CH2:16][CH2:15]3)=[N:12][N:13]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178489119HCID 178489119, compound

Product 1

HCID 178489120HCID 178489120, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[4-({4-[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]-3-phenyl-1,6-naphthyridin-5(6H)-one (300 mg, 0.53 mmol) was dissolved in MeOH and TFA (40 μL, 0.53 mmol) was added. The solvent was evaporated under reduced pressure and the yellow residue was dried under high vacuum for 16 h to give 2-[4-({4-[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]-3-phenyl-1,6-naphthyridin-5(6H)-one trifluoroacetate.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe yellow residue was dried under high vacuum for 16 h

Sources & evidence

ORD record
ord-60ec76d8a8b1467d985d336bb673b1e1
Source dataset
uspto-grants-2011_03
Patent number
US07910561B2

Reaction notes

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