反应详情

The product from Example 143 was reacted according to the procedure from Example 150 substituting the product from Example 143 for the product from Example 138 to provide a residue which was purified by trituration with methanol and diethyl ether to provide the title compound (26 mg, 55%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.37 (d, J=6.99 Hz, 6H), 3.21-3.43 (m, 1H), 6.83 (s, 1H), 6.84 (d, J=8.82 Hz, 2H), 6.92 (d, J=8.09 Hz, 1H), 7.02 (d, J=8.09 Hz, 2H), 7.32 (d, J=8.46 Hz, 2H), 7.63 (d, J=8.09 Hz, 1H), 7.93 (dd, J=8.46, 1.84 Hz, 1H), 7.99 (s, 1H), 8.94 (s, 1H), 9.08 (d, J=8.46 Hz, 1H), 9.51 (s, 1H), 9.74 (s, 1H), 10.02 (s, 1H); MS (APCI) m/z 524 (M+H)+.

1. customto provide a residue which
2. customwas purified by trituration with methanol and diethyl ether