反应详情

2-(2-(1-(tert-Butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)benzenesulfonamide. The title compound was prepared from 2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(tributylstannyl)oxazole (71 mg, 0.107 mmol) and 2-iodobenzenesulfonamide following General Procedure A. Flash chromatography (2-10% EtOAc/hexanes) yielded the title compound as a clear oil (25 mg, 44%): 1H NMR (CDCl3, 400 MHz) δ 8.18 (d, 1H, J=7.6 Hz), 7.62-7.59 (m, 2H), 7.54-7.51 (m, 1H), 7.42-7.39 (m, 1H), 7.36 (s, 1H), 7.24-7.22 (m, 2H), 7.16-7.12 (m, 2H), 5.29 (ex s, 2H), 4.88 (t, 1H, J=6.7 Hz), 2.56 (t, 2H, J=7.6 Hz), 1.86-1.84 (m, 2H), 1.62-1.59 (m, 2H), 1.31-1.29 (m, 6H). 0.86 (s, 9H), 0.09 (s, 3H), 0.00 (s, 3H); 13C NMR (CDCl3, 100 MHz) δ 170.7, 153.6, 148.0, 144.9, 137.9, 135.7, 134.6, 134.3, 133.6, 133.4, 133.3, 131.0, 130.8, 42.3, 41.1, 36.3, 34.9, 34.3, 34.3, 31.0, 30.0, 23.5, 0.4, 0.0.