反应详情

2-(1-(tert-Butyldimethylsilyloxy)-7-phenylheptyl)-5-(4-methoxypyridin-2-yl)oxazole. The title compound was prepared from 2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(tributylstannyl)oxazole (144 mg, 0.302 mmol) and 2-chloro-4-methoxypyridine following General Procedure A. Flash chromatography (10% EtOAc/hexanes) yielded the title compound as a thick oil (88 mg, 61%): 1H NMR (CDCl3, 400 MHz) δ 8.43 (d, 1H, J=5.6 Hz), 7.63 (s, 1H), 7.28-7.24 (m, 2H), 7.18-7.15 (m, 3H), 6.75 (dd, 1H, J=5.8, 2.6 Hz), 4.85 (dd, 1H, J=7.3, 5.8 Hz), 3.9 (s, 3H), 2.59 (t, 2H, J=7.6 Hz), 1.93 (m, 2H), 1.61 (m, 2H), 1.36 (m, 4H), 0.90 (s, 9H), 0.10 (s, 3H), 0.01 (s, 3H); 13C NMR (CDCl3, 100 MHz) δ 166.3, 165.5, 151.1, 150.6, 148.9, 142.7, 128.3, 128.2, 125.5, 125.3, 109.0, 105.1, 68.7, 55.3, 36.4, 35.9, 31.4, 29.1, 25.7, 25.7, 25.1, 18.2, −5.0, −5.1.