反应详情

To 10.0 g of 2,4-difluoro-3-methoxybenzoic acid was added 40 mL of tetrahydrofuran. To this solution was added 0.4 mL of N,N-dimethylformamide, and then 8 mL of thionyl chloride was added dropwise with stirring to this mixture at room temperature. After completion of the dropwise addition, Dimroth condenser was installed, and the mixture was heated under reflux for 2 hours. After allowing the reaction mixture to cool, the solvent was distilled away. The resulting acid chloride was dissolved in 40 mL of tetrahydrofuran, and 12 ml of triethylamine was added to this solution and the mixture was stirred. After 30 minutes, 8.37 g of ethyl N,N-dimethylaminoacrylate was added dropwise, and after completing the dropwise addition, the mixture was heated under reflux for 2 hours. After completion of the reaction, the precipitated solid was removed by suction filtration, and the filtrate was concentrated under reduced pressure to obtain 23.3 g of the desired title compound as a dark brown oily compound.

1. additionAfter completion of the dropwise addition, Dimroth condenser
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hours
4. temperatureto cool
5. distillationthe solvent was distilled away
6. dissolutionThe resulting acid chloride was dissolved in 40 mL of tetrahydrofuran
7. addition12 ml of triethylamine was added to this solution
8. stirringthe mixture was stirred
9. addition8.37 g of ethyl N,N-dimethylaminoacrylate was added dropwise
10. additionthe dropwise addition
11. temperaturethe mixture was heated
12. temperatureunder reflux for 2 hours
13. customAfter completion of the reaction
14. customthe precipitated solid was removed by suction filtration
15. concentrationthe filtrate was concentrated under reduced pressure