反应详情

To 2,6-bis(3-cyanophenoxy)pyridine-4-carboxylic acid, ethyl ester (1.6 g, 4.0 mmol) in tetrahydrofuran/water (50 mL, 1/1) was added lithium hydroxide (0.85 g, 20 mmol). After stirring for 1.5 hours the reaction was partitioned with 1 M HCl and ethyl acetate. The organic layer was separated, dried (MgSO4), and the solvent was removed in vacuo. The residue was dissolved in methylene chloride (50 mL) and thionyl chloride (2.4 g, 20 mmol) was added. After stirring for 2 hours the solvent was removed in vacuo. The residue was dissolved in methylene chloride/water (30/10 mL) and methylamine hydrochloride (0.090 g, 1.3 mmol) and potassium carbonate (0.46 g, 3.3 mmol) were added. The organic layer was separated, washed with brine, dried (MgSO4), and the solvent removed in vacuo to give 2,6-bis(3-cyanophenoxy)-N-methylpyridine-4-carboxamide; NMR (CDCl3) 7.5 (m,4), 7.3 (m,4), 7.0 (s,2), 6.25 (br s,1), 3.1 (d,3) ppm.

1. customwas partitioned with 1 M HCl and ethyl acetate
2. customThe organic layer was separated
3. dry with materialdried (MgSO4)
4. customthe solvent was removed in vacuo
5. dissolutionThe residue was dissolved in methylene chloride (50 mL)
6. stirringAfter stirring for 2 hours the solvent
7. customwas removed in vacuo
8. dissolutionThe residue was dissolved in methylene chloride/water (30/10 mL)
9. customThe organic layer was separated
10. washwashed with brine
11. dry with materialdried (MgSO4)
12. customthe solvent removed in vacuo