反应详情

To a suspension of 4-hydroxy-6-phenyl-3-(phenylmethyl)amino-2H-pyran-2-one, monohydrochloride (0.153 mmol) in ethyl acetate (10 ml) was added N-methylmorpholine (2.0 ml) and tert-butyl isocyanate (2.0 ml). The reaction was allowed to stir for 2.5 hrs and then quenched by dilution with ethyl acetate. The organic layer was washed with 5% citric acid and saturated sodium chloride and was dried over anhydrous magnesium sulfate. After evaporation of the solvents in vacuo the crude product was purified by column chromatography (silica gel-230 to 400 mesh) using 5% methanol in dichloromethane as eluents.

1. customquenched by dilution with ethyl acetate
2. washThe organic layer was washed with 5% citric acid and saturated sodium chloride
3. dry with materialwas dried over anhydrous magnesium sulfate
4. customAfter evaporation of the solvents in vacuo the crude product
5. customwas purified by column chromatography (silica gel-230 to 400 mesh)