Sodium Hydroxide → HCID 178525977, compound

HRID 614236Notes

Reaction equation

HRID 614236 reaction equation
C([O:3][C:4]([CH2:6][O:7][CH2:8][C:9]1[N:13](CC2C=CC(OC)=CC=2)[C:12]([SH:23])=[N:11][N:10]=1)=[O:5])C.C(OC(COCC(NN)=O)=O)C.[OH-].[Na+]>>[C:4]([CH2:6][O:7][CH2:8][C:9]1[N:13]=[C:12]([SH:23])[NH:11][N:10]=1)([OH:5])=[O:3]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 20377449HCID 20377449, compoundHCID 178473061HCID 178473061, compound

Product 1

HCID 178525977HCID 178525977, compound

Procedure

By employing a procedure similar to that described in Example XVI, Part A, 3-(ethoxycarbonylmethoxymethyl)-4(p-methoxybenzyl)-1,2,4-triazole-5-thiol was prepared from ethoxycarbonylmethoxyacetohydrazide. The ethoxycarbonyl group was then hydrolyzed to the free acid using aqueous 2N sodium hydroxide, and the p-methoxybenzyl blocking group was thereafter removed by using trifluoroacetic acid in a manner similar to that earlier described in Example XVI, Part B to finally give pure 3-(carboxymethoxymethyl)-1,2,4-triazole-5-thiol, m.p. 180°-182° C.

Workup

  1. customthe p-methoxybenzyl blocking group was thereafter removed

Sources & evidence

ORD record
ord-46379ca1280e47b4b97a0789c0de0e0f
Source dataset
uspto-grants-1979_03
Patent number
US04144240

Reaction notes

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