Methyl vinyl ketone → Ethyl 2-(isonicotinoyl)-5-oxohexanoate

HRID 616605ノート

反応式

HRID 616605 の反応式
[C:1]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH:15]([C:17]([CH3:19])=[O:18])=[CH2:16]>>[C:1]([CH:9]([CH2:16][CH2:15][C:17](=[O:18])[CH3:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 6570Methyl vinyl ketoneHCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionate

生成物 1

HCID 9835014Ethyl 2-(isonicotinoyl)-5-oxohexanoate

実験手順

3-(4-Pyridinyl)-2-cyclohexen-1-one is obtained by modifying the procedure described in Example B-1 as follows: Ethyl isonicotinoylacetate and methyl vinyl ketone are reacted as in Example B-1 to yield ethyl 2-(isonicotinoyl)-5-oxohexanoate which is then reacted with 35% aqueous sodium hydroxide solution at 25°-30° C. to produce ethyl 3-(4-pyridinyl)-2-cyclohexen-1-one-4-carboxylate and the 4-carboxylate is heated with aqueous sulfuric acid at 95° C. until the evolution of carbon dioxide ceases, thereby producing 3-(4-pyridinyl)-2-cyclohexen-1-one.

出典と根拠

ORDレコード
ord-fa1be62694214af39bc7618629ad3153
出典データセット
uspto-grants-1978_02
特許番号
US04075217

反応ノート

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