HRID619797

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68007

Benzene, 1-(bromomethyl)-3-fluoro-

C7H6BrF

结构：COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4cccc(C#N)c4)C3=O)cc2c1

HCID10550854

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2ccc(S(=O)(=O)N(Cc3cccc(F)c3)[C@H]3CCN(Cc4cccc(C#N)c4)C3=O)cc2c1

HCID67365504

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as described in EXAMPLE 25, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 43, part A, and 3-fluorobenzyl bromide. The crude product is purified by column chromatography eluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes to afford the title compound as a white foam.

WORKUP

后处理

customThe title compound is prepared
customprepared
customThe crude product is purified by column chromatography
washeluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-472e61ff6a384903a3e60baba6bbb6ae
来源数据集: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05958918
来源说明: uspto-grants-1999_09

反应 SMILES

[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2].[F:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH2:36]Br>>[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:36][C:35]2[CH:38]=[CH:39][CH:40]=[C:33]([F:32])[CH:34]=2)[S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2]