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HRID619806

反应详情

EQUATION

反应方程式

HRID 619806 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc2ccc(S(=O)(=O)Cl)cc2c1
HCID10515266

7-methoxynaphthalene-2-sulfonyl Chloride

C11H9ClO3S

结构：Cl.N#Cc1cccc(CN2CC[C@H](N)C2=O)c1
HCID22870786

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2ccc(S(=O)(=O)N[C@H]3CN(Cc4cccc(C#N)c4)C3=O)cc2c1
HCID67365870

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as in EXAMPLE 24, Part B substituting 3-(3-(S)-Amino-2-oxo-azetidin-1-ylmethyl)benzonitrile hydrochloride for 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride and using 7-methoxynaphthalene-2-sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 20% EtOAc/CH2Cl2 to 30% EtOAc/CH2Cl2 to give the title compound as a white solid.

WORKUP

后处理

  1. customThe title compound is prepared as in EXAMPLE 24, Part B
  2. customThe crude product is purified by column chromatography
  3. washeluting with a gradient of 20% EtOAc/CH2Cl2 to 30% EtOAc/CH2Cl2