HRID619842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7498

alpha-Bromotoluene

C7H7Br

结构：COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4csc(C#N)c4)C3=O)cc2c1

HCID10670821

未命名化合物

结构：Cc1c(S(=O)(=O)N[C@H]2CCN(Cc3csc(C#N)c3)C2=O)sc2ccc(Cl)cc12

HCID18392446

未命名化合物

PRODUCTS

生成物

结构：Cc1c(S(=O)(=O)N(Cc2ccccc2)[C@H]2CCN(Cc3csc(C#N)c3)C2=O)sc2ccc(Cl)cc12

HCID57229291

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as in EXAMPLE 126, Part A using 5-chloro-3-methylbenzo[b]thiophene-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as in EXAMPLE 129, Part A, in place of 7-methoxynaphthalene-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide and benzyl bromide in place of MeI. The crude product is purified by column chromatography eluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes to afford the title compound as a white solid.

WORKUP

后处理

customThe title compound is prepared as in EXAMPLE 126, Part A
customThe crude product is purified by column chromatography
washeluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e7ca366c9efb45b589c47438b9874526
来源数据集: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05958918
来源说明: uspto-grants-1999_09

反应 SMILES

[C:1]([C:3]1[S:7][CH:6]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([NH:14][S:15]([C:18]3[S:22][C:21]4[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=4[C:19]=3[CH3:28])(=[O:17])=[O:16])[C:10]2=[O:29])[CH:4]=1)#[N:2].C(C1SC=C(CN2CC[C@H](NS([C:47]3[CH:56]=[CH:55][C:54]4[C:49](=[CH:50]C(OC)=CC=4)[CH:48]=3)(=O)=O)C2=O)C=1)#N.C(Br)C1C=CC=CC=1>>[C:1]([C:3]1[S:7][CH:6]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([N:14]([CH2:50][C:49]3[CH:54]=[CH:55][CH:56]=[CH:47][CH:48]=3)[S:15]([C:18]3[S:22][C:21]4[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=4[C:19]=3[CH3:28])(=[O:17])=[O:16])[C:10]2=[O:29])[CH:4]=1)#[N:2]