反应详情

2 g (4.7 mmol) of 2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene are heated at the reflux temperature in 15 ml of ethanol with 2 g of methylammonium chloride for 6 hours. After cooling, the salts are filtered off with suction, the solution is evaporated, the residue is taken up in chloroform and the mixture is washed with water. The organic phase is dried and concentrated and the residue is chromatographed on silica gel with chloroform with 1% of methanol. Intensely yellow crystals are obtained from ethanol.

1. temperatureAfter cooling
2. filtrationthe salts are filtered off with suction
3. customthe solution is evaporated
4. washthe mixture is washed with water
5. customThe organic phase is dried
6. concentrationconcentrated
7. customthe residue is chromatographed on silica gel with chloroform with 1% of methanol
8. customIntensely yellow crystals are obtained from ethanol