Hydrochloric Acid → 5-Amino-2-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-4(3H)-pyrimidone
Reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([N+:22]([O-])=O)=[CH:17][N:16]=2)=[CH:7][CH:6]=1)[CH3:3].COCCO.Cl>[Ni]>[NH2:22][C:18]1[C:19](=[O:21])[NH:20][C:15]([NH:14][CH2:13][CH2:12][S:11][CH2:10][C:8]2[O:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:6][CH:7]=2)=[N:16][CH:17]=1Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-5-nitro-4(3H)-pyrimidone (4.26 g; 12.05 mmoles) in 50 ml of 2-methoxyethanol containing 1.55N methanolic HCl (7.75 ml; 12.01 meq.) was added a catalytic amount of Raney nickel No. 28 (approximately 2.8 cm3), and the mixture was hydrogenated in a Parr apparatus at 50 psi for 1.25 hours. The reaction mixture was filtered, treated with 20 ml of 1.55N methanolic HCl and evaporated under reduced pressure. The residue was placed on 190 g of silica gel and chromatographed by flash chromatography using CH3OH:CH3CN:NH4OH (20:80:1) as eluent. The appropriate fractions were combined and evaporated to dryness. The residue was dissolved in 25 ml (38.8 meq.) of 1.55N methanolic HCl, evaporated under reduced pressure and dried under high vacuum at 56° C. to give 3.53 g of the title compound as a trihydrochloride, mp 127°-132° C.
Workup
- filtrationThe reaction mixture was filtered
- additiontreated with 20 ml of 1.55N methanolic HCl
- customevaporated under reduced pressure
- customchromatographed by flash chromatography
- customevaporated to dryness
- customevaporated under reduced pressure
- customdried under high vacuum at 56° C.
Sources & evidence
- ORD record
- ord-d7504e79ba394a9d8a9ed861d272869c
- Source dataset
- uspto-grants-1988_09
- Patent number
- US04772704
Reaction notes
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