反应详情

2-(4-Fluorophenyl)-4-methyl-2H-1,2,3-triazole 1-oxide (i.e. the product of Step A, 6.6 g, 34 mmol) was added to acetic anhydride (47 mL, 500 mmol), and the reaction mixture was stirred at reflux for 28 h. The reaction was concentrated under reduced pressure. The residue was taken up in ethyl acetate, washed successively with water and saturated aqueous sodium chloride solution, dried with magnesium sulfate and concentrated under reduced pressure to afford the title compound (7.8 g) as a beige solid. The title compound was used directly in the next step without further purification.

1. temperatureat reflux for 28 h
2. concentrationThe reaction was concentrated under reduced pressure
3. washwashed successively with water and saturated aqueous sodium chloride solution
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated under reduced pressure