反应详情

To a solution of 2-(benzyloxy)-4-ethyl-1-(2-fluoro-4-nitro phenoxy)benzene (25 g; 68 mmol) in ether (86 mL), under argon cooled to 0° C., was added a suspension of tin dichloride (153 g; 801 mmol) in HCl (50 mL; 2 mol). The mixture was allowed to warm up to room temperature overnight, then a 10% NaOH solution was added dropwise. The resulting mixture was extracted with ethyl acetate (5*400 mL). Combined organic phases were washed with water (400 mL) and brine, then dried over Na2SO4 and concentrated. The residue was purified on silica gel (ethyl acetate/cyclohexane 1:9) to yield the title compound as a light brown solid (15.8 g; 68.8%)

1. additionwas added
2. extractionThe resulting mixture was extracted with ethyl acetate (5*400 mL)
3. washCombined organic phases were washed with water (400 mL) and brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe residue was purified on silica gel (ethyl acetate/cyclohexane 1:9)