反应详情

(4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone from the previous step in 20 mL 40% HBr was refluxed for 1 h., neutralized with solid Na2CO3 at 0° C., and extracted with EtOAc. The extract was washed with brine, dried, concentrated, and purified by column chromatography (eluent: petroleum ether/EtOAc=5/1 to 2/1) over silica gel to give the subtitle compound (731 mg, 51% yield for 3 steps) as a yellow solid.

1. extractionextracted with EtOAc
2. washThe extract was washed with brine
3. customdried
4. concentrationconcentrated
5. custompurified by column chromatography (eluent: petroleum ether/EtOAc=5/1 to 2/1) over silica gel