反应详情

102 mg (0.2 mmol, purity 72%) of rac-tert-butyl 1-(3-{[cyclopent-1-en-1-yl(3,4-dihydroisoquinolin-2(1H)-yl)acetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate were initially charged in 14.4 ml of methanol, 14.4 mg (0.06 mmol) of platinum(IV) oxide were added and the mixture was hydrogenated at RT and standard pressure for 5 h. The mixture was then filtered through kieselguhr, the residue was washed thoroughly with methanol and the filtrate was concentrated under reduced pressure. This gave 102 mg (purity 36%) of the title compound which was reacted further without purification.

1. customwas hydrogenated at RT
2. filtrationThe mixture was then filtered through kieselguhr
3. washthe residue was washed thoroughly with methanol
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThis gave 102 mg (purity 36%) of the title compound which was reacted further without purification