反应详情

The title compound was prepared from (S)-tert-butyl 2-((tert-butyldimethylsilyloxy)methyl)-3-ethyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 207, 5.146 g, 13.92 mmol) according to the procedure described for Intermediate 8, except the mixture was stirred at ambient temperature for 1 h. The mixture was concentrated and diluted with aqueous NH4Cl, water and EtOAc. The organic layer was separated and washed three times with brine, dried over Na2SO4, filtered and concentrated to afford the title compound (5.19 g, 100%) as a cloudy oil.

1. concentrationThe mixture was concentrated
2. additiondiluted with aqueous NH4Cl, water and EtOAc
3. customThe organic layer was separated
4. washwashed three times with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated