反应详情

The title compound was prepared using 6-bromo-4-chloro-3-phenylquinoline (Intermediate 3, step c) and (3-fluorophenyl)(6-chloropyridin-3-yl)methanone in place of 6-bromo-2,4-dichloro-3-phenylquinoline and (3-chlorophenyl)(pyridin-3-yl)methanone, respectively, according to the procedure described in Example 25. 1H NMR (400 MHz, CDCl3) δ 8.81 (s, 1H), 8.40 (d, J=2.69 Hz, 1H), 8.30 (d, J=2.20 Hz, 1H), 8.10 (d, J=8.80 Hz, 1H), 7.68 (ddd, J=2.20, 8.62, 17.55 Hz, 2H), 7.46-7.54 (m, 5H), 7.33 (d, J=8.56 Hz, 2H), 7.05-7.11 (m, 3H); MS m/e 474.9 [M+H]+.