反应详情

TBAF (1M in THF) (1.35 mL, 1.35 mmol) was added to a solution of tert-butyl(4-fluoro-3,5-diisopropoxybenzyloxy)dimethylsilane (6) (600 mg, 1.35 mmol) in THF at 0° C. and the mixture was stirred at this temperature for 1 h. The mixture was partitioned between NH4Cl (satd. aq.) (50 mL) and EtOAc (100 mL). The phases were separated and the organic solution was washed with brine (50 mL), then dried over MgSO4 and filtered. The solvent was removed in vacuo and the residue was purified by silica gel chromatography (40 g, 0-50% EtOAc in isohexane) to afford (4-fluoro-3,5-diisopropoxyphenyl)methanol (7) (382 mg, 100%) as a colourless oil.

1. customThe mixture was partitioned between NH4Cl (satd. aq.) (50 mL) and EtOAc (100 mL)
2. customThe phases were separated
3. washthe organic solution was washed with brine (50 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customThe solvent was removed in vacuo
7. customthe residue was purified by silica gel chromatography (40 g, 0-50% EtOAc in isohexane)