反应详情

4-Benzyloxy-3,5-difluoro-benzaldehyde (1.2 g, 4.83 mmol) obtained in Step B and carbethoxymethylene triphenylphosphorane (2.0 g, 5.78 mmol) was dissolved in THF (10 mL), and the solution was stirred at 65˜75° C. for 1 hour. After the termination of the reaction, the reactant was cooled and concentrated under reduced pressure. The residue was purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (1.2 g, 78%).

1. customAfter the termination of the reaction
2. temperaturethe reactant was cooled
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by column chromatography (eluent, EtOAc/Hex=1/10)