反应详情

To a suspension of ethyl 5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylate (2.50 g, 6.85 mmol, prepared as in Example 82, Step 1) in THF (20 mL) was added 1.0 M NaOH (20 mL, 20 mmol) and the reaction was stirred overnight. Concentrated HCl was added to acidify (to pH ˜2). The product was extracted with ethyl acetate. The combined extracts were dried over sodium sulfate, filtered and concentrated to afford a white solid. The yield was close to theoretical and the product was used without further purification.

1. extractionThe product was extracted with ethyl acetate
2. dry with materialThe combined extracts were dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customto afford a white solid
6. customThe yield was close to theoretical and the product
7. customwas used without further purification