反应详情

2-Bromo-5-chloro-1H-pyrrolo[3,2-b]pyridine (2.0 g, 8.6 mmol, prepared as in Example 103, Step 1) in DMF (20. mL) was treated with K2CO3 (1.8 g, 13 mmol) and m-cyanobenzyl bromide (1.9 g, 9.5 mmol, Aldrich) overnight. The reaction mixture was diluted with EtOAc and washed sequentially with water and brine. The combined organic extracts were dried over sodium sulfate, filtered and concentrated. The solid obtained was triturated with hexanes/diethyl ether and isolated by filtration. Yield: (2.3 g, 77%).

1. washwashed sequentially with water and brine
2. dry with materialThe combined organic extracts were dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe solid obtained
6. customwas triturated with hexanes/diethyl ether
7. customisolated by filtration