反应详情

(4-Hydroxy-phenyl)-acetic acid methyl ester (1.0 g, 6.02 mmol) was dissolved in DMF (10 mL), and K2CO3(2.5 g, 18.06 mmol) was added thereto. Benzyl chloride (0.83 mL, 7.22 mmol) was added slowly thereto, and the mixture was stirred at 40˜50° C. for 12 hours. The reactant was cooled and concentrated under reduced pressure. The residue was added with water and then extracted with EtOAc. The organic layer was concentrated under reduced pressure, and the residue was purified by column chromatography (eluent, EtOAc/Hex=1/4) to obtain the title compound (1.4 g, 91%).

1. temperatureThe reactant was cooled
2. concentrationconcentrated under reduced pressure
3. additionThe residue was added with water
4. extractionextracted with EtOAc
5. concentrationThe organic layer was concentrated under reduced pressure
6. customthe residue was purified by column chromatography (eluent, EtOAc/Hex=1/4)