反应详情

To tert-butyl (2R,5R)-5-(hydroxymethyl)-2-[2-(2-{[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]amino}phenyl)ethyl]morpholine-4-carboxylate (1 eq) in DMF (0.1M) at rt were added PDC (10 eq) and 4A molecular sieve (1 g/mmol of substrate). The reaction mixture was stirred at rt for 16 hrs. The reaction mixture was then filtered on a celite and the celite pad was washed with EtOAc and water. The filtrate was extracted with EtOAc. The combined organic layers were washed with brine, 1N aqueous HCl and brine, dried over Na2SO4, filtered and concentrated. The crude product was used as such for next step.

1. filtrationThe reaction mixture was then filtered on a celite
2. washthe celite pad was washed with EtOAc and water
3. extractionThe filtrate was extracted with EtOAc
4. washThe combined organic layers were washed with brine, 1N aqueous HCl and brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated