反应详情

To a solution of tert-butyl (2R,5R)-2-ethynyl-5-(tert-butyldimethylsilyloxy-methyl)morpholine-4-carboxylate (Example 79, step 4) (2.0 g, 5.7 mmol) in 20 mL of THF was added tetrabutylammonium fluoride (1.0 M in THF, 15 mL, 15 mmol). The solution was stirred at ambient temperature for 1 h and then diluted with EtOAc, washed with aqueous NH4Cl, and brine. The solution was dried (MgSO4), filtered, and the solvent was removed in vacuo. The residue was chromatographed on an 80 g SiO2 column using a gradient elution of 0-10% MeOH in CHCl3 to give the product as an oil.

1. washwashed with aqueous NH4Cl, and brine
2. dry with materialThe solution was dried (MgSO4)
3. filtrationfiltered
4. customthe solvent was removed in vacuo
5. customThe residue was chromatographed on an 80 g SiO2 column
6. washa gradient elution of 0-10% MeOH in CHCl3