反应详情

27 mg (0.0703 mmol) of 5-nitro-2-(4′-trifluoromethyl-[1,1′-biphenyl]-4-yl)benzo[d]oxazole was dissolved in methanol, and then, 10% Pd/C was added thereto to allow a catalytic reaction therebetween for 4 hours under hydrogen gas atmosphere. The reaction solution was diluted with ethyl acetate. Then, the diluted reaction solution was filtered with a celite pad, and then, was concentrated under reduced pressure. Afterwards, the filtered reaction solution was purified by using a silica gel column chromatography (ethyl acetate/normal-hexane at a volume ratio of 1:1) to obtain 13.6 mg (54.6%) of 2-(4′-trifluoromethyl-[1,1′-biphenyl]-4-yl)benzo[d]oxazole-5-amine (Derivative #8).

1. customa catalytic reaction
2. customThen, the diluted reaction solution
3. filtrationwas filtered with a celite pad
4. concentrationwas concentrated under reduced pressure
5. customAfterwards, the filtered reaction solution
6. customwas purified