(3-Methylpyridin-2-yl)methanamine → N4-cyclohexyl-5,6-dimethyl-N2-[(3-methylpyridin-2-yl)methyl]pyrimidine-2,4-diamine

HRID 63116Notes

Reaction equation

HRID 63116 reaction equation
Cl.[CH:2]1([NH:8][C:9]2[C:14]([CH3:15])=[C:13]([CH3:16])[N:12]=[C:11]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[N:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:25]C1C(CN)=NC=CC=1>>[CH:2]1([NH:8][C:9]2[C:14]([CH3:15])=[C:13]([CH3:16])[N:12]=[C:11]([NH:17][CH2:18][C:19]3[C:24]([CH3:25])=[CH:23][CH:22]=[CH:21][N:20]=3)[N:10]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 1514370(3-Methylpyridin-2-yl)methanamineHCID 131737202N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine hydrochloride

Product 1

HCID 71738407N4-cyclohexyl-5,6-dimethyl-N2-[(3-methylpyridin-2-yl)methyl]pyrimidine-2,4-diamine

Procedure

The titled compound was synthesized according to the general procedure described for preparation of N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 1) using [(3-methylpyridin-2-yl)methyl]amine instead of (pyridin-2-ylmethyl)amine. The crude product was purified by crystallization from ethanol (10 mL) to afford the titled compound as the hydrochloride salt as a white solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.10-1.20 (m, 5H), 1.55-1.75 (m, 5H), 1.89 (s, 3H), 2.25 (s, 3H), 2.33 (s, 3H), 3.83 (s, 1H), 4.63 (d, J=5.10 Hz, 2H), 7.15-7.25 (m, 1H), 7.50-7.65 (m, 2H), 7.91 (s, 1H), 8.34 (d, J=4.03 Hz, 1H), 12.62 (s, 1H); MS (ESI) m/z 326.9 (M+1)+.

Workup

  1. customThe titled compound was synthesized
  2. customThe crude product was purified by crystallization from ethanol (10 mL)

Sources & evidence

ORD record
ord-00e64d9f14634a4f948d989639f5e98c
Source dataset
uspto-grants-2016_09
Patent number
US09447051B2

Reaction notes

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