反应详情

温度

25 °C

In a 250 mL round-bottomed flask, 5-(4-bromo-2-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid ethyl ester (291 mg, 887 μmol) was combined with tetrahydrofuran (18 mL) to give a colorless solution. 1M LiOH (9 mL, 9.00 mmol, Eq: 10.1) was added and the reaction was stirred at 25° C. for 15 h. The crude reaction mixture was concentrated in vacuo and acidified with 10 mL of 1M HCl. The reaction was diluted with EtOAc and the organic layer was washed with H2O (1×20 mL) and saturated NaCl (1×20 mL), dried over Na2SO4 and concentrated in vacuo. The white powder was dried under vacuum to afford 266 mg (100%) of the desired product. (M−H)−=297.8 and 299.9 (m/e).

1. customto give a colorless solution
2. customThe crude reaction mixture
3. concentrationwas concentrated in vacuo
4. additionThe reaction was diluted with EtOAc
5. washthe organic layer was washed with H2O (1×20 mL) and saturated NaCl (1×20 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo
8. customThe white powder was dried under vacuum