反应详情

温度

50 °C

To a solution of 108.4 mg (0.142 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 26, in 2 ml of methanol, 0.5 ml of 2 N hydrochloric acid was added, and the mixture was stirred at 50° C. for 3 hours. After completion of the reaction, 0.5 ml of 2 N sodium hydroxide aqueous solution was added to the reaction solution, then saturated sodium chloride aqueous solution was added, and the reaction solution was extracted with ethyl acetate. The obtained organic phases were combined, washed with saturated sodium chloride aqueous solution, dried with magnesium sulfate and then filtered, and the solvent was distilled off under reduced pressure to provide 101.2 mg of the title compound as a white solid (yield: 99%).

1. additionwas added to the reaction solution
2. extractionthe reaction solution was extracted with ethyl acetate
3. washwashed with saturated sodium chloride aqueous solution
4. dry with materialdried with magnesium sulfate
5. filtrationfiltered
6. distillationthe solvent was distilled off under reduced pressure