反应详情

温度

110 °C

(7R,8aS)-N-(2-chloro-5-fluoropyrimidin-4-yl)-octahydro-5,5-dimethylindolizin-7-amine (1.4525 g. 4.86 mmol) and p-toluenesulfonic acid (1.7288 g, 9.09 mmol) were weighed out and added to a large reaction tube containing 1-(5-amino-2-bromo-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one (2.10 g, 7.29 mmol). 42 mL isopropyl alcohol was added, and the tube was sealed and heated overnight at 110° C. The reaction was basified with saturated aqueous sodium bicarbonate and extracted three times with ethyl acetate. The combined organic layer was washed with brine and dried over sodium sulfate. Product solution was filtered, concentrated onto a plug of silica, and purified by column chromatography. Pure fractions were combined, concentrated and dried under high vacuum to give 1.4063 g of the title compound (53% yield).

1. additionadded to a large reaction tube
2. customthe tube was sealed
3. extractionextracted three times with ethyl acetate
4. washThe combined organic layer was washed with brine
5. dry with materialdried over sodium sulfate
6. filtrationProduct solution was filtered
7. concentrationconcentrated onto a plug of silica
8. custompurified by column chromatography
9. concentrationconcentrated
10. customdried under high vacuum