Hydrochloric Acid → HCID 57730483, compound

HRID 63501Notes

Reaction equation

HRID 63501 reaction equation
[CH3:1][S:2](O)(=O)=O.[NH2:6][CH2:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[C:13](=[O:17])[N:12]([CH:18]1[CH2:23][CH2:22][C:21](=[O:24])[NH:20][C:19]1=[O:25])[CH2:11]2.[F:26][C:27]([F:39])([F:38])[S:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1N=C=S.Cl.C(#[N:43])C>>[O:25]=[C:19]1[CH:18]([N:12]2[CH2:11][C:10]3[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][NH:6][C:1]([NH:43][C:32]4[CH:31]=[CH:30][C:29]([S:28][C:27]([F:26])([F:38])[F:39])=[CH:34][CH:33]=4)=[S:2])[CH:9]=3)[C:13]2=[O:17])[CH2:23][CH2:22][C:21](=[O:24])[NH:20]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 866307653-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione methanesulfonateHCID 86630770(Trifluoromethylthio)phenyl isothiocyanate

Product 1

HCID 57730483HCID 57730483, compoundYield 48%

Conditions

Temperature
0 °C

Procedure

TEA (0.28 g, 2.8 mmol) was added to a mixture of 3-(5-aminomethyl-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione methanesulfonate (0.50 g, 1.4 mmol) and -(trifluoromethylthio)phenyl isothiocyanate (0.33 g, 1.4 mmol) in acetonitrile (30 mL) at 0° C. The mixture stirred at 0° C. for 16 h, and then 4% aqueous HCl solution (30 mL) was added. The solid precipitate was filtered and dried in vacuo providing 1-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-3-(4-trifluoromethylsulfanyl-phenyl)-thiourea as a white solid (0.33 g, 48% yield); mp 229-231° C.; HPLC, Waters Symmetry C-18, 3.9×150 mm, 5 μm, 1 ml/min, 240 nm, 50/50 CH3CN/0.1% H3PO4, 4.08 (98.31%); 1H NMR (DMSO-d6) δ 1.98-2.04 (m, 1H), 2.32-2.47 (m, 1H), 2.57-2.63 (m, 1H), 2.86-2.98 (m, 1H), 4.32 (d, 1H, J=17.4 Hz), 4.46 (d, 1H, J=17.4 Hz), 4.89 (d, 2H, J=5.4 Hz), 5.12 (dd, 1H, J=13.2 Hz, J=5.1 Hz), 7.48 (d, 1H, J=8.4 Hz), 7.56 (s, 1H), 7.64-7.73 (m, 5H), 8.60 (s, 1H), 10.02 (s, 1H), 10.99 (s, 1H); 13C NMR (DMSO-d6) δ 22.5, 31.2, 47.0, 47.1, 51.6, 116.2, 122.2, 122.8, 122.9, 127.2, 129.6 (q, J=306), 130.5, 136.8, 142.3, 142.7, 143.0, 167.9, 171.0, 172.8, 180.8; LCMS: MH=509; Anal. Calcd for C22H19P3N4O3S2+0.1H2O: C, 51.78; H, 3.79; N, 10.98. Found: C, 51.55; H, 3.55; N, 10.85.

Workup

  1. customat 0° C
  2. filtrationThe solid precipitate was filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5be3b75579a044b5a8183b74ee0087af
Source dataset
uspto-grants-2016_09
Patent number
US09447070B2

Reaction notes

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