2,3-Dihydro-1,4-benzodioxin-6-methylamine → N-(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)-10-[(2-methoxy-2'-methyl-1,1'-biphenyl-4-YL)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide
반응식
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([O:34][CH3:35])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[O:38]1[C:43]2[CH:44]=[CH:45][C:46]([CH2:48][NH2:49])=[CH:47][C:42]=2[O:41][CH2:40][CH2:39]1>>[O:38]1[C:43]2[CH:44]=[CH:45][C:46]([CH2:48][NH:49][C:3]([C:5]3[N:14]4[C:8]([CH2:9][N:10]([C:19]([C:21]5[CH:26]=[CH:25][C:24]([C:27]6[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=6[CH3:33])=[C:23]([O:34][CH3:35])[CH:22]=5)=[O:20])[C:11]5[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=5[CH2:13]4)=[CH:7][CH:6]=3)=[O:4])=[CH:47][C:42]=2[O:41][CH2:40][CH2:39]1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and C-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-methylamine. Purification was performed using HPLC with a normal phase column and eluting with a two phase solvent system (A=hexane, B=dichloromethane/methanol, 4:1), m.p. 153-155° C. MS [(+)ESI, m/z]: 600 [M+H]+
후처리
- customPurification
- washeluting with a two phase solvent system (A=hexane, B=dichloromethane/methanol, 4:1), m.p. 153-155° C
출처 및 근거
- ORD 기록
- ord-884dbebd4b9e402a8a079d25e04ed865
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691848B2
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