反应详情

A mixture of 1.0 g (4.3 mmol) Methyl-furo[2,3-b]quinoline-4-carboxylate 6, 12 ml methanol and 60 mL 1N NaOH was heated at reflux for 75 minutes. After cooling the solution was acidified with 4N HCl to pH ˜1-2, whereupon a solid precipitated. Then the reaction mixture was extracted with 200 mL diethylether. The organic layer was separated and extracted now with 150 mL of a sodium bicarbonate solution (5%), wich was acidified another time with 4N HCl to give the product 7 as a crystalline solid. The precipitate was filtered and dried under vacuum to give 760 mg of 7.

1. temperaturewas heated
2. temperatureat reflux for 75 minutes
3. temperatureAfter cooling the solution
4. customprecipitated
5. extractionThen the reaction mixture was extracted with 200 mL diethylether
6. customThe organic layer was separated
7. extractionextracted now with 150 mL of a sodium bicarbonate solution (5%), wich