反应详情

A solution of N-(5-(6-(6-(benzyloxy)pyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-2′,4′-difluoro-[1,1′-biphenyl]-3-yl)ethanesulfonamide (0.140 g, 0.234 mmol) in TFA (5 ml) was stirred at RT for 16 h. The mixture was concentrated on vacuo, quenched with sodium bicarbonate and extracted as in Example 1(d). The solvent was distilled off to give the product in 23.7% yield (0.028 g). 1H NMR (400 MHz, DMSO-d6): δ 10.35 (s, 1H), 9.07 (s, 1H), 8.70 (s, 1H), 8.44 (s, 1H), 8.01 (d, 1H), 7.93 (s, 2H), 7.78-7.72 (m, 2H), 7.48-7.45 (d, 2H), 7.30-7.26 (t, 1H), 6.52-6.50 (d, 1H), 3.30-3.28 (q, 2H), 1.28-1.25 (t, 3H); LC-MS (ESI): Calculated mass: 507.51; Observed mass: 508.1 [M+H]+ (rt: 0.1 min).

1. concentrationThe mixture was concentrated on vacuo
2. customquenched with sodium bicarbonate
3. extractionextracted as in Example 1(d)
4. distillationThe solvent was distilled off
5. customto give the product in 23.7% yield (0.028 g)
6. custom508.1 [M+H]+ (rt: 0.1 min)