反应详情

Similarly prepared as per compound 8 procedure, using (S)-2-(2,3-dichlorophenyl) propanoic acid 7 and compound 4 (4-pyridine) to obtained title compound Q60 as white solid (71%). 1H NMR (CDCl3, 400 MHz) δ 1.72 (d, J=6.8 Hz, 3H), 3.95 (dq, J=7.2 Hz, J=3.2 Hz, 1H), 4.79 (d, J=2.8 Hz, 1H), 6.56 (d, J=8.4 Hz, 1H), 6.96 (d, J=8 Hz, 1H), 7.09 (t, J=8 Hz, 1H), 7.46 (dd, J=9.2 Hz, J2=2 Hz, 1H), 7.54 (d, J=8.4 Hz, 1H), 8.06 (d, J=4 Hz, 2H), 8.09 (d, J=1.6 Hz, 1H), 8.56 (s, 1H), 8.8 (bs, 2H); 13C NMR (CDCl3, 100 MHz) δ 20.0, 56.4, 110.8, 111.1, 112.4, 118.6, 119.6, 120.9, 121.2, 128.4, 133.5, 134.3, 134.7, 142.4, 144.1, 148.0, 150.9, 161.7, 171.7; C21H17N4O2Cl2 (M+H)+ calcd. 427.0729 found 427.0724.