2-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamide → 2-[2-(2-tert-Butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)-benzoylamino]-4-chloro-N-(5-chloropyridin-2-yl)benzamide

HRID 644197Notes

Reaction equation

HRID 644197 reaction equation
[NH2:1][C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][N:8]=1)=[O:5].[C:19]([O:23][C:24]([NH:26][CH2:27][CH2:28][O:29][C:30]1[CH:38]=[C:37]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[CH:36]=[CH:35][C:31]=1[C:32](O)=[O:33])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([NH:26][CH2:27][CH2:28][O:29][C:30]1[CH:38]=[C:37]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[CH:36]=[CH:35][C:31]=1[C:32]([NH:1][C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][N:8]=1)=[O:5])=[O:33])=[O:25])([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 219061992-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamideHCID 576024442-(2-Tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoic acid

Product 1

HCID 578607922-[2-(2-tert-Butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)-benzoylamino]-4-chloro-N-(5-chloropyridin-2-yl)benzamideYield 74%

Procedure

Using methods substantially equivalent to those described in Example 29-G, 2-[2-(2-tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoylamin]-4-chloro-N-(5-chloropyridin-2-yl)benzamide was prepared in a 74% yield from 2-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamide and 2-(2-tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoic acid.

Sources & evidence

ORD record
ord-fee27ccc1b574016bc4def88a2c1425d
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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