反应详情

温度

80 °C

In 10 ml of tetrahydrofuran was dissolved 1.2 g of 2-(benzyloxycarbonylaminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole obtained by Example 11. To the solution was added 10 ml of 5N-HCl, and the mixture was stirred for 2 hours at 80° C. Tetrahydrofuran was evaporated off under reduced pressure. The remaining aqueous layer was made alkaline with 2N-NaOH, which was subjected to extraction with ethyl acetate. The extract was washed with water and dried, then the solvent was evaporated off. The residue was purified by means of a silica-gel column chromatography [eluent: chloroform-methanol (9:1)] to give 0.5 g (yield 60%) of 2-(aminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole.

1. customTetrahydrofuran was evaporated off under reduced pressure
2. extractionwas subjected to extraction with ethyl acetate
3. washThe extract was washed with water
4. customdried
5. customthe solvent was evaporated off
6. customThe residue was purified by means of a silica-gel column chromatography [eluent: chloroform-methanol (9:1)]