反应详情

温度

80 °C

To 2-(N-methyl(benzoylaminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole obtained by Example 13 was added 20 ml of 5N-HCl, and the mixture was stirred for 2 hours at 80° C. The reaction solution was left standing for cooling, which was then made alkaline with 2N-NaOH. The alkaline solution was subjected to extraction with ethyl acetate. The extract solution was washed with water, dried and concentrated under reduced pressure, followed by purification by means of a silica-gel column chromatography [eluent: chloroform-methanol (9:1)] to give 2.1 g (yield 91%) of 4-(4-methoxyphenyl)-2-methylaminomethyl-5-(3-pyridyl)-1,3-thiazole. Compounds prepared after the manner described in the above Examples 1-9 are exemplified in Table 1. Melting points are all uncorrected.

1. waitThe reaction solution was left
2. temperaturefor cooling
3. extractionThe alkaline solution was subjected to extraction with ethyl acetate
4. washThe extract solution was washed with water
5. customdried
6. concentrationconcentrated under reduced pressure
7. customfollowed by purification by means of a silica-gel column chromatography [eluent: chloroform-methanol (9:1)]