反应详情

14.5 g of (S)-2-(ethylsulfonylamino)-3-methyl-butyric acid N-[2-(4-benzyloxy-3-methoxy-phenyl)-ethyl]-amide are dissolved in 420 ml of tetrahydrofuran and, together with 3 g of 5% palladium on active carbon, shaken in a hydrogenation vessel for 5 hours in a hydrogen atmosphere under normal pressure. The catalyst is then filtered off. The filtrate is concentrated. The residue is purified by flash chromatography on silica gel with ethyl acetate/n-hexane 3:1, yielding (S)-2-(ethylsulfonylamino)-3methyl-butyric acid N-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-amide in the form of a colourless oil.

1. filtrationThe catalyst is then filtered off
2. concentrationThe filtrate is concentrated
3. customThe residue is purified by flash chromatography on silica gel with ethyl acetate/n-hexane 3:1