反应详情

温度

-10 °C

A 3-neck, 100 mL round-bottom flask was charged with the product from Example 22D (412.6 mg, 3.5 mmol) and anhydrous THF (15 mL) under N2 atmosphere. The reaction was cooled to −10° C. Cyclohexylmethylmagnesium bromide (7 mL, of a 1.0M solution in ether, 7 mmol) was added dropwise. The reaction was stirred for 1 hour, warmed to room temperature, and stirred for an additional 3 hours. The reaction was quenched with 10 mL THF/1M HCl (1:1). The aqueous and organic layers were separated. The pH ofthe aqueous layer was adjusted to 3 with 1M HCl. The aqueous layer was extracted with EtOAc (3×10 mL). All organic layers were combined and washed with brine, dried (MgSO4), and concentrated under vacuum. The residue was purified by silica gel column (1:1 EtOAc/hexanes) to provide 425.2 mg (58%) of the title compound as an orange oil.

1. temperaturewarmed to room temperature
2. stirringstirred for an additional 3 hours
3. customThe reaction was quenched with 10 mL THF/1M HCl (1:1)
4. customThe aqueous and organic layers were separated
5. extractionThe aqueous layer was extracted with EtOAc (3×10 mL)
6. washwashed with brine
7. dry with materialdried (MgSO4)
8. concentrationconcentrated under vacuum
9. customThe residue was purified by silica gel column (1:1 EtOAc/hexanes)