反应详情

To a solution fo 880 mg (10 mmol) of 1,4-diaminobutane in tetrahydrofuran (20 ml) was added in an argon atmosphere a solutin fo 410 mg (1 mmol) of N-{5-(3-methoxy-4-β-methoxyethoxymethoxyphenyl)-2,4-pentadienoyl}-2-thiothiazolidine in tetrahydrofuran (10 ml) at room temperature over 30 min. The mixture was treated in the same way as in Example 3 to react with 390 mg (1.05 mmol) of α-linolenic acid thiazolidinethionamide. The reaction product was treated in the same way as in Example 3 to hydrolyze N-{5-(3-methoxy-4-β-methoxyethoxymethoxyphenyl)-2,4-pentadienoyl}-N'-9,12,15-octadecatrieneo yl-1,4-diaminobutane with 1,4-dioxane - acetic acid-water (5:4:1). The reaction product was treated in the same way as in Example 3 to give 195 mg (0.35 mmol) of N-{5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoyl}-N'- 9,12,15-octadecatrienoyl-1,4-diaminobutane. Spectrophotometric data of the product support the structure shown below. ##STR31##

1. additionwas added in an argon atmosphere a solutin
2. customat room temperature
3. customover 30 min
4. additionThe mixture was treated in the same way as in Example 3
5. additionThe reaction product was treated in the same way as in Example 3
6. additionThe reaction product was treated in the same way as in Example 3