反应详情

A solution of (2S,4R)-1-t-butoxycarbonyl-2-[(Z)-5-carboxy-1-pentenyl]-4-(4-chlorophenylsulfonylamino)pyrrolidine (2.90 g) in methanol (50 ml) saturated with hydrogen chloride was stirred at room temperature overnight and the solvent was evaporated in vacuo. The residue was dissolved in chloroform (50 ml) and the solution was washed successively with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over magnesium sulfate and the solvent was evaporated in vacuo to give (2S,4R)-4-(4-chlorophenylsulfonylamino)-2-[(Z)-5-methoxycarbonyl-1-pentenyl]pyrrolidine (2.28 g) as a pale brown oil.

1. customthe solvent was evaporated in vacuo
2. dissolutionThe residue was dissolved in chloroform (50 ml)
3. washthe solution was washed successively with saturated aqueous sodium bicarbonate and brine
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customthe solvent was evaporated in vacuo