4-Amino-1-butanol → 1-(4-Chloro-3-trifluoromethylphenyl)-3-{4-[2-(4-hydroxy-butylamino)-pyrimidin-4-yloxy]-phenyl}-urea

HRID 659005ノート

反応式

HRID 659005 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][C:3]=1[C:29]([F:32])([F:31])[F:30].[NH2:33][CH2:34][CH2:35][CH2:36][CH2:37][OH:38]>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21]([NH:33][CH2:34][CH2:35][CH2:36][CH2:37][OH:38])[N:20]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][C:3]=1[C:29]([F:32])([F:31])[F:30]

参加物

4

反応物 2

HCID 258684-Amino-1-butanolHCID 675239201-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea

生成物 1

HCID 249976521-(4-Chloro-3-trifluoromethylphenyl)-3-{4-[2-(4-hydroxy-butylamino)-pyrimidin-4-yloxy]-phenyl}-urea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 216 mg (0.444 mmol) 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea, 87.0 mg (0.976 mmol) 4-amino-butan-1-ol and 5 ml THF was stirred at r.t. for 12 h. The reaction mixture was evaporated and the residue purified by chromatography on silica (dichloromethane/ethanol 96:4). Yield 127 mg (58%) of the title compound.

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue purified by chromatography on silica (dichloromethane/ethanol 96:4)

出典と根拠

ORDレコード
ord-71fea07f44634b0bbbdf9377540e133e
出典データセット
uspto-grants-2011_12
特許番号
US08080552B2

反応ノート

読み込み中…