反应详情

A mixture of 216 mg (0.444 mmol) 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea, 87.0 mg (0.976 mmol) 4-amino-butan-1-ol and 5 ml THF was stirred at r.t. for 12 h. The reaction mixture was evaporated and the residue purified by chromatography on silica (dichloromethane/ethanol 96:4). Yield 127 mg (58%) of the title compound.

1. customThe reaction mixture was evaporated
2. customthe residue purified by chromatography on silica (dichloromethane/ethanol 96:4)