反应详情

N-(2-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-ethyl)-C-cyclohexyl-methanesulfonamide (0.106 g, 0.17 mmol) is dissolved in THF (3 mL) and TBAF (0.089 mg, 0.099 mL of 1N in THF, 0.34 mmol) is added. The mixture is refluxed for 30 min and then diluted with 1N HCl and extracted with EtOAc. The combined organic layers are washed with 1N HCl, dried over MgSO4 and evaporated to afford the title compound.

1. temperatureThe mixture is refluxed for 30 min
2. extractionextracted with EtOAc
3. washThe combined organic layers are washed with 1N HCl
4. dry with materialdried over MgSO4
5. customevaporated